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Literature summary extracted from

  • Chatterjee, K.; Thornton, J.L.; Bauer, J.W.; Vogler, E.A.; Siedlecki, C.A.
    Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition (2009), Biomaterials, 30, 4915-4920.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.38 additional information usage of measurement of prekallkrein hydrolysis to kallikrein by activated factor XII at test hydrophilic clean glass and hydrophobic silanized glass surfaces in the presence of bovine serum albumin, BSA. Activation after contact of the zymogen FXII with a test hydrophobic surface to activated FXII occurs only if putatively adsorbed FXIIa is competitively displaced by BSA, model for the sequence of events involving prekallikrein and FXII at solid procoagulant surfaces, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 prekallikrein + H2O Homo sapiens
-
 kallikrein + kallikrein prepeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.38 proteolytic modification activation of zymogen FXII to FXIIa by autoactivation Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 additional information usage of measurement of prekallkrein hydrolysis to kallikrein by activated factor XII at test hydrophilic clean glass and hydrophobic silanized glass surfaces in the presence of bovine serum albumin, BSA. Activation after contact of the zymogen FXII with a test hydrophobic surface to activated FXII occurs only if putatively adsorbed FXIIa is competitively displaced by BSA, overview. An anionic hydrophilic surface is not a necessary cofactor for FXIIa-mediated hydrolysis of PK, and PK hydrolysis does not need to occur by an activation complex assembled directly on an anionic, activating surface. Contact activation of FXII (autoactivation) is not specific to anionic hydrophilic surfaces. Protein-adsorption competition is an essential feature that must be included in any comprehensive mechanism of surface-induced blood coagulation. Activation of zymogen FXII to FXIIa by autoactivation Homo sapiens ?
-
 ?
3.4.21.38 prekallikrein + H2O
-
 Homo sapiens kallikrein + kallikrein prepeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 activated factor XII
-
 Homo sapiens
3.4.21.38 FXIIa
-
 Homo sapiens